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Answer:
Small and lipid soluble cortisol can pass through nonpolar core of the plasma membrane.
Explanation:
Cortisol is a lipid-soluble steroid hormone with a compact structure. The plasma membrane is a bilayer of phospholipids.
The phospholipids are amphipathic molecules with a polar head and nonpolar tails. The nonpolar tails of the two layers of phospholipids are packed away from the watery medium and make the core of the plasma membrane.
Being a lipid-soluble hormone with a small structure, cortisol can pass through the nonpolar core of the plasma membrane easily to activate its receptors and alter the gene expression.

All cells contain a nucleus
Explanation is in the pic
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A mutation is a genetic error in the creation of DNA. My science teacher compared it to a copier that made a mistake; the DNA is copied from others, but the "copier" messed up, making part of a helix different. Mutations can be genotypes or phenotypes.