Answer:
percent of maximal heart rate method; most accurate
Explanation:
the percent of maximal heart rate method is one of two methods of determining target heart rates. this method is considered the most accurate but it is a bit more difficult to calculate than the other method.
If a proteins shape was changed it may be able to do its function to do being unable to fit in all blood vessels/arteries and the shape change may of hindered its capability of carrying nutrients it needs to transport, etc.
for example:
If a hemoglobin (red blood cell) shape changed, (this is normally called sickle cell) the red blood cell would be to unable to travel through the body with ease and easily clog bloodstreams. Also, the hemoglobin will not be able to transport as much oxygen throughout the body.
I think it can. You're becoming more addicted the more marijuana you use; eventually you'll want to move on to something more powerful once you get used to the effects of the drug.
Hope this helps!