19.24 The mechanism for acetal hydrolysis has been heavily investigated. In one study, which explored rates as well as stereoche
mical aspects,[5] compound 1 was treated with aqueous acid to afford compound 2. Draw the structure of 2, clearly showing the configuration of any chiral center(s). c19s124
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Answer:
a. The resonance effect of the hydroxyl group stabilizes the anionic intermediate
Explanation:
The resonance effect stabilizes the the charge through the delocalization of the pi bonds. The resonance stabilization mainly occurs in the conjugated pi systems.
For example, phenol forms a strong hydrogen bonds than the nonaromatic alcohols as the dipole present in the hydroxyl group is being stabilized by the presence of the aromatic ring of phenol.
Thus the resonance effect of the hydroxyl group stabilizes the anionic intermediate.