Heterozygote advantage occurs when heterozygotes have a higher fitness than do both homozygotes. In frequency-dependant selection, the fitness of a phenotype declines it it becomes too common in the population.
Explanation;
The heterozygotes have both alleles, which is needed for genetic variation. Heterozygotes are essential for there to be genetic variation in a population. In other words it is when When a single copy of a disease allele doesn't result in a disease but instead is good for the person or organism that carries it, we say that allele has a heterozygote advantage. For example a sickle cell trait, which protects against malaria in heterozygotes, but causes a deadly disease in homozygotes.
-Frequency-dependent selection occurs when the fitness of a genotype depends on its frequency. It is possible for the fitness of a genotype to increase (positively frequency-dependent) or decrease (negatively frequency-dependent) as the genotype frequency in the population increases.
Alport we from Indiana and he was born in the year 1898. In his opportunistic functioning theory, Alport alleged that people are motivated by the need to satisfy their biological survivals. Although he said this theory is not important in trying to understand the behaviors of people. According to him this theory is reactive and also biological.