Mental disorder is multiple conditions that affect the mood, behavior, and thinking of a person.
If u mean the endocrine system .The endocrine system is the collection of glands of an organism that secrete hormones directly into the circulatory system to be carried towards distant target organs.
Fat soluble drugs (a type of drug that dissolves in the fat tissue) like antianxiety drug clorazepate can affect the brain dissolving tissue.
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