Answer:
crab and lobster
Explanation:
they have the most similar genetic background
Answer:
Extracellular fluid
Explanation:
A proportion of this fluid is plasma
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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We know, only 10% of energy transferred from each trophic level. Plant can capture 1% energy from the sun. According 10% law only 10% energy transfer to next level. Thus if plant has 1%- trophic level 2 will have 0.1%; then third trophic level will have 0.01% and we human if we are on fourth level then we will have 0.001%.
Thus correct answer is 0.001%.
Answer:
Juxtaglomenular is a structure in the kidney which regulates the function of each nephron, the functional units of the kidney. The main function of the juxtaglomerular cells is to secrete renin in response to:
Stimulation of the beta-1 adrenergic receptor
Decrease in renal perfusion pressure (detected directly by the granular cells)
Decrease in NaCl concentration at the macula densa, often due to a decrease in glomerular filtration rate
Explanation:
The juxtaglomerular apparatus is a specialized structure formed by the distal convoluted tubule and the glomerular afferent arteriole. It is located near the vascular pole of the glomerulus and a structure in the kidney that regulates the function of each nephron, the functional units of the kidney.
