Colchicine is a drug that can prevent the formation of microtubules. By blocking the synthesis of spindle microtubules, it will stop mitosis in cell division.
A traditional anti-mitotic medication called colchicine prevents mitotic cells from dividing during metaphase. It forms tubulin-colchicine complexes with soluble tubulin in an imperfectly reversible way, which bind to the ends of microtubules to stop the elongation of the microtubule polymer.
Colchicine is an alkaloid from the Colchicum autumnale plant that prevents microtubule polymerization, which is thought to be necessary for collagen production. This substance is therefore thought to function as an antifibrotic substance by inhibiting collagen production and deposition.
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In early 1803, Jefferson appointed James Monroe as a special envoy to France. Monroe and Minister to France Robert Livingston would try to buy land east of the Mississippi or in New Orleans itself, or, if all else failed, to secure U.S. access to the river. Jefferson authorized them to negotiate up to $10 million.
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