Answer: the process in which a cell changes from one cell type to another. Usually, the cell changes to a more specialized type. Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types.
The epithelial tissue found in areas subject to considerable friction and abuse, such as the skin, is the stratified squamous epithelium.
Stratified squamous is an epithelial tissue that consist of many layers of flattened cells, the simple squamous is an epithelial tissue consisting of one layer of cells flattened like fish scales, The simple cuboidal consists of one layer of cube-shaped cells while the stratified cuboidal are epithelial tissue consisting of two layers of cube shaped cells.
The organelle malfunctioning in this case is lysosome. They have powerful enzymes and acids to digest and recycle cell material so they remove waste from the cell.