Galactosemia can result from a deficiency of either galactokinase or UDP-glucose:galactose 1-phosphate uridylytransferase (trans
ferase). Although a deficiency of either enzyme will cause gastric discomfort after milk ingestion, transferase deficiency also results in liver, kidney, spleen, and brain dysfunction, and in some cases, death. Select the statements that correctly link each type of enzyme deficiency with the metabolites that accumulate in the blood and tissues a. A deficiency in either enzyme will result in an accumulation of lactose; however, a transferase deficiency will also cause an accumulation of the toxic product UDP-galactose
b. A transferase deficiency will result in an accumulation of the toxic metabolite galactosse 1-phosphate.
c. A galactokinase deficiency will cause an accumulation of galactose.
d. A galactokinase deficiency will result in an accumulation of galactose 1-phosphate
e. A transferase deficiency will cause an accumulation of UDP-glucose.
b. A transferase deficiency will result in an accumulation of the toxic metabolite galactosse 1-phosphate.
c. A galactokinase deficiency will cause an accumulation of galactose.
Explanation:
Transferase is an enzyme which is responsible for the breakdown of galactose which is a known milk sugar. Its deficiency causes the formation of toxic materials such as galactose-1-phosphate which comes from galactose, and galactitol. Galactokinase is also an enzyme which helps in the conversion of galactose into galactose 1-phosphate with the expenditure of ATP molecule, so its deficiency causes the deposition of galactose.
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