Physical change as no new substance is created
The answer to this question would be: vitamin
Some bacteria can produce vitamin K2 in the intestine. Other bacteria also able to change vitamin K1 into vitamin K2. But the amount produced is not much, so human still need to fulfill it from the diet. Vitamin K has a role in calcium regulation and in blood clotting pathway.
Controls what substances can move in and out of the cell. it also protects the cell from its surroundings.