Answer:
Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation.
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<u><em>Hope this helps :)</em></u>
<u><em>Pls brainliest...</em></u>
Scientific law. For example, Law of Universal Gravitation.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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This map shows the precipitation pattern in different parts of Florida.
Certain crops require a specific amount of annual rainfall to be successful. Which statement explains why coconut palm trees are successful in Florida?
They need an annual rainfall of 8 to 16 inches.
They need an annual rainfall of 16 to 24 inches.
They need an annual rainfall of at least 30 to 50 inches.
They need an annual rainfall of at least 120 to 140 inches.1 Attachment<span> <span>art004.gif</span></span>
Answer:
D
Explanation:
The changes in eating noted in the first study are due to fibers that are passing through the lateral hypothalamus. The lateral hypothalamus is a region of the brain with a key function of coordinating an array of cognitive and physical processes such as feeding
