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Nadya [2.5K]
3 years ago
13

Sometimes drugs, such as phenobarbital, are given in a higher dose as a loading dose and then tapered back to a maintenance dose

. This helps the drug to accumulate to a therapeutic level in the body until the concentration plateaus. When this occurs, the drug has reached which of the following?
a.Nadir
b.Steady state
c.Half-life
d.Bioavailability
Biology
1 answer:
nika2105 [10]3 years ago
5 0

Answer:

b.Steady state

Explanation:

When a drug is in a steady state is usually defined as the time during which the drug remains stable when administered repeatedly or continuously (IV infusion) - this is the state where the rate of the drug entering the systemic circulation or drug administration equals to its rate of elimination out of the system. In the case where a drug is administered multiple times in fixed intervals the plasma concentration increases till it plateaus. This administration pattern will  result in a steady-state concentration which is intended to be within the therapeutic window

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Answer:

D --  ATP synthesis when the phosphate donor is a substrate with high phosphoryl transfer potential

Explanation:

Substrate- level phosphorylation is the synthesis of ATP from ADP by the transfer of phosphoryl group from a substrate with high phosphoryl group potential to the ADP molecule.

In substrate-level phosphorylation, the donor is a phosphorylated intermediate molecule with a high phosphate transfer potential and it is a way through which phosphate in introduced into a molecule, the other two ways are oxidative phosphorylation and photophosphorylation. In substrate-level phosphorylation, a PO4^2- is transferred from a phosphate intermediate (substrate) to ADP to form ATP. Phosphorylase and kinases are enzymes involved in this reaction. An example is the reaction in glycolysis which involves phosphoenolpyruvate and ADP to form Pyruvate and ATP. This is to ensure adequate supply of energy to cells and also during anoxia so as not to make mitochodria strain the glycolytic ATP reserves.

7 0
3 years ago
The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3′ hydroxyl group (–OH)
Dima020 [189]

Answer:

There won't be any functional viral DNA synthesis

Explanation:

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Hence, wherever acyclovir was integrated, there won't be any chance to form a 5'-3' phosphodiester bond. The protomolecule will not be stable and will soon be degradated.

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Vlad [161]

Answer:

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6 0
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<h3>The phosphorus cycle</h3>

Phosphorus cycles between living components of the earth (biosphere) and the soil (geosphere).

The element's reservoir is mainly the sediments of the ocean and rocks. Phosphorus gets into the soil by weathering of rocks.

Plants are able to pick the element up from the soil and animals are able to get their phosphorus by consuming plants.

When plants and animal die, their body decomposes and the phosphorus in them enters the soil.

Thus, the cycle being referred to in the illustration is the phosphorus cycle.

More on phosphorus cycle can be found here: brainly.com/question/15020567

#SPJ1

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