Question

A child who is being evaluated for an immune deficiency fails to make antibody to tetanus toxoid or pneumococcal vaccine, but shows normal cell-mediated immunity as indicated by a positive skin test (swelling and redness) to a commonly encountered environmental antigen. this child has an abnormality of which cell lineage? think in: cellular immunity vs humoral immunity

Answer 1

The answer is B cell lineage. There two stages of B cells Lineage first is the early pro b cell -D and J rearrangement and the late Pro B cell - V-DJ rearrangement. These rearrangements refer to the Heavy chain and activation of KIT causes the B-cell to proliferate.

Answer 2

The right answer is B cell lineage.

B cells (LB) or B cell, whose letter "B" comes from the "Bursa of Fabricius" (bird organ in which LBs mature), mature in humans, in the spinal cord bone. They are responsible for the specific humoral immune response by the antibodies they produce that will be used for the specific recognition and destruction of the pathogen.

B cells also act as antigen presenting cells.

The antibodies are immunoglobulins secreted by plasma cells (differentiated B cells), which act as mediators of humoral immunity. They have the property of binding specifically to the antigen thus leading to three complementary effects: neutralization, opsonization and complement activation.

Vaccination can trigger an immune response in the body. This leads to the establishment of a defense that can be of two types: humoral (B cells) or cellular (T cells).

Humoral immunity causes the body to produce antibodies to respond to the introduction of an antigen. It is set up following an injection of an inert vaccine such as that against tetanus.