myosin heads form cross bridges and pull thin filaments causing them to slide.
the presence of acetocholene causes calcium to be released causing depolarization of the sarcoplasmic reticulum and changing its shape. the myofilaments together with actin allows the myosin to form cross bridges along the muscle fibers and releases ATP for movement of the muscle.
A disease that is affecting too many people at a global scale is called a Pandemic disease and <u>one good example of this kind of disease is the Spanish Influenza of 1918 that killed around 50 million people</u>.