3 illnesses of the skeletal system: 1. OSTEOMYELITIS - is bone inflammation that often results from bacterial infection, and it can lead to complete destruction of the bone. 2. OSTEOMALACIA- or the softening of the bones, resulting from calcium depletion from bones. 3. OSTEOGENESIS IMPERFECTA- a genetic disorder producing very brittle bones that easily fractured, occurs because insufficient collagen or abnormal collagen is formed.