art career of cause
Explanation:
mm because i think that is the best for artists
The endosymbiosis explains how eukaryotic cells may have evolved from prokaryotic cells.
Answer:
Nitrogen and phosphorus are among the elements considered most limiting to plant growth and productivity because they are often present in small quantities locally or are present in a form that cannot be used by the plant.
Explanation:
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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Answer:
a. the RNA polymerase undergoes abortive initiation prior to promoter clearance
Explanation:
In eukaryotes the 3' end of the mRNA is polyadenylated to protect the mRNA from degradation.
In eukaryotes, a modified guanine cap is added to the 5' end of the mRNAd to protects the transcript from being broken down.
Most bacterial RNA transcripts do not undergo splicing.
The nucleosome is the basic unit of chromatin repeat in eukaryotes.
