Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are the tissue disorders which can be characterized by chronic pain, joint instability complications, and minor skin changes. During these, Fatigue and headache are the very common symptoms; though they can be diagnosed using specific criteria.
JHS/EDS-HT is a rare common condition that could not be diagnosed by most clinicians and pain specialists, resulting in interventions like symptomatic and non-satisfactory treatments, because there is a lack of reasonable pathophysiologic rationale.
Pain, fatigue, and headache in JHS/EDS are usually treated with the help of certain symptoms or on the basis of doctors’ experience.
<span>Therefore, in order to the cure of such symptoms, doctors suggest pathogenic mechanisms. The major aim of the re-writing of the natural history of JHS/EDS-HT is to raise awareness among clinical geneticists and specialists treating chronic pain conditions about pain and other complications of JHS/EDS-HT.</span>
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Nicotinamide adenine dinucleotide (NAD+) and flavin adenine dinucleotide (FAD+) are two cofactors that are involved in cellular respiration. They are responsible for accepting "high energy" electrons and carrying them ultimately to the electron transport chain where they are used to synthesize ATP molecules.
