The sensory neurons senses it
Well the hormone would be one thing. I'd say because it strengthens our heart muscles and trains our breathing pattern to be more effective. These would lead to more efficient transportation of blood and hence oxygen to our whole body including our brain. Our brain becomes more alert, and our body more energetic.
The answer most likely would be Viruses.
Good luck
Hope this helps u
Administer a tablet under his tongue and repeat the action in 5 and 10 minutes if the pain has not subsided.