If you are referring to President Franklin D. Roosevelt's first fireside chat about the Great Depression than here are the correct answers:
1) The loss of savings for many workers- Thousands of individuals invested their money in the stock market thinking it was a safe investment. When Black Thursday hit and the stock market crashed, people lost their entire life savings due to their investment in different stocks.
2) The loss of credit in the economy. - The failure of America's stock market and banks represented a significant loss in credit within the US.
3) Growing economic challenges for many- The Great Depression resulted in high uenmployment rates, an increase in the homeless population, thousands of banks shutting down across the country, etc.