Answer:
Thermosensitive liposomes (TSL) are promising tools used to deliver drugs to targeted region when local hyperthermia is applied (∼40–42°C) which triggers the membrane phase transformation from a solid gel-like state to a highly permeable liquid state. Selective lipid components have been used to in TSL formulations to increase plasma stability before hyperthermia and speed drug release rate after. Two generations of TSL technology have been developed. The traditional thermal sensitive liposomes (TTSL) have utilized DPPC and DSPC as a combination. The second generation, lysolipid thermally sensitive liposomes (LTSL) technology, has been developed with incorporation of lysolipids that form stabilized defects at phase transition temperature. LTSL maintains certain favorable attributes:
High percentage of lysolipids incorporation;
Minimum leakage for therapeutical drugs encapsulation;
Ultrafast drug release upon heating (3.5 times enhanced compared to TTSL). For example, ThermoDox, a commonly used LTSL drug for cancer, has been reported to release 100% of the encapsulated doxorubicin within 30s;
First and most successful formulation for intravascular drug release.
Explanation:
https://www.creative-biostructure.com/Lysolipid-Thermally-Sensitive-Liposomes-Production-612.htm
- Provide the family with lead education
- Consider treating the child with appropriate chelation therapy
- Refer the child to a clinical center specializing in lead poisoning
If the blood lead level<span> of a preschooler is found to be between 20 and 44 mcg/dL, the nurse should provide lead education to the family. The nurse should also consider treating the child with appropriate chelation therapy. The nurse may refer the child to a clinical center specializing in lead poisoning. The nurse should refer the child to social services if the child’s blood lead level is between 15 and 19 mcg/dL. The nurse should immediately provide diagnostic testing and initiate chelation therapy if the child’s blood lead level is 70 mcg/dL or greater.</span>
Cellular respiration takes place in the mitochondria
<u>Answer</u>: A heritable trait can be changed from one generation to another.
<u>Explanation</u>:
- The concept of <em>descent with modification</em> was given by Darwin which simply states that the traits are passed on from the parents to the offsprings.
- The traits that can be passed on are known as <em>heritable traits</em>.
- These traits are passed on with the help of the genes.
- So this passing on of traits explains the term <em>descent</em> in this concept. However, there are always chances that these heritable traits can be changed due to environmental factors or due to the process of recombination and thus the term <em>modification</em>.
- So <em>descent with modification</em> means that a<em> heritable trait is passed from parents to offspring but it can be changed from one generation to another.</em>
