Answer:
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ T regulatory cells) and B cells are involved in this disorder, thus new MS therapies seek damage prevention by resetting multiple components of the immune system. The currently approved therapies are immunoregulatory and reduce the number and rate of lesion formation but are only partially effective. This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation. The translational options target oligodendrocyte protection and myelin repair in animal models and assess their relevance in human. Remyelination may be enhanced by signals that promote myelin formation and repair. The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.Keywords: calpain, central nervous system, demyelination, fingolimod, glycolipids, lipids, multiple sclerosis, myelin, myelination, NKT cells, oligodendrocytes, remyelination, T cells
Explanation:
In order to improve fitness, the body may be subjected to larger loads or levels of resistance than it is typically used to.
<h3>What advantages do workouts have?</h3>
Physical activity is good for your bones and muscles, your brain, your weight, your risk of disease, your capacity to carry out daily tasks, and your ability to manage your weight. Adults who engage in any quantity of moderate-to-vigorous physical activity and sit less will experience some health benefits.
This is not advised since you risk causing muscular damage. In order to make the workout more severe and so develop fitness, it is actually advised that you increase the repetitions each set, use various weights, and change the type of exercise often.
Learn more about physical activity here:
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B. say that you need to call a friend for a ride
Answer:
The correct answer is C)
Explanation:
Studies have shown that most adverts would rather use smiling faces or happy faces than any other because humans are wired to respond to and happiness.
This is attributable to our neural programming. In humans, a set of neurons called the <em>mirror neurons</em> cause us to experience the emotions being communicated by a facial expression that we look at.
So people are more likely to accept a product or service or a message that makes them happy. To achieve this, the advertisers put a happy face or a smilling face to the advertisement.
Cheers!
Answer:
After delivery, the doctor or midwife usually closes the perineal tear with stitches. The stitches will dissolve in 1 to 2 weeks, so they will not need to be removed. You may notice pieces of the stitches on your sanitary pad or on the toilet paper when you go to the washroom (:
