Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Answer:
b. Frank received the mutant chromosome from his father. Nondisjunction occurred in his father during the first meiotic division.
Explanation:
As you can see in the question above, Frank has Klinefelter syndrome which causes him to have normal skin patches and skin patches without sweat glands. Her mother has completely normal hair, which may indicate that the defective gene was not supplied by her. In addition, Frank's father has anhydrotic ectodermal dysplasia, an X-linked condition where the skin does not contain sweat glands.
Although Frank's father's defective gene is linked to the X chromosome, it is likely that Frank inherited the defective gene from his country. This may have occurred because during meiosis I, his father's genes did not show disjunction. As a result, Frank presents a mosaic of his phenotype, because an inactivation of the X chromosome occurred.
Answer:
The incorporation of radiolabeled amino acids during protein synthesis occurs when the data shows the organelles involved with protein synthesis, packaging and transport, that is, radioactivity levels would increase first at the rough endoplasmic reticulum, followed by the Golgi, and then the secretory vesicles (option C).
Explanation:
Protein synthesis in the cell occurs when RNA -which contains the sequence of triplets or codons that make up the genetic code- is coupled to ribosomes.
Each codon or triplet, consisting of three nucleotides, will give instructions for specific amino acids to be incorporated into the polypeptide chain that is being synthesized in the rough endoplasmic reticulum.
The Golgi apparatus is responsible for packaging or packaging the newly synthesized proteins in secretory vesicles for transport.
<em>In consecuense, </em><u><em>radioactivity levels would increase in the organelles involved in protein synthesis, packaging and transport, the rough endoplasmic reticulum, Golgi apparatus and secretory vesicles</em></u><em>, respectively.</em>
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Learn more:
Steps of protein synthesis brainly.com/question/884041
<span>A six-carbon sugar is an example of a molecule </span><span>that can join with other molecules to form a carbohydrate such as starch or cellulose.</span>
The statement that is true is B. <span>Dissolved minerals from rocks are deposited in the ocean. All of the other statements are not correct, they are false.</span>
