Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The shorter the food chain, the larger amount of energy obtained.
Hence, the consumer furthest away from the producer obtains the least energy.
The quaternary consumer is furthest away. Most energy is lost by then. Hence, it has access to the smallest supply of energy.
Answer:
See the answer below.
Explanation:
Antibiotic-producing bacteria are generally known to have a mechanism that enables them to be resistant to their own antibiotics. The mechanism that enables them to be resistant to their own antibiotic depends largely on the mode of action of the antibiotic substance.
Some of the popular mechanisms used by bacteria to counter their own antibiotic substance include a mutation in the target gene, production of enzymes that inactivate the antibiotic compounds, or efflux of the compounds.
<u>In the case of </u><u><em>Streptomyces griseus</em></u><u>, the inactivity of streptomycin has been linked with the production of a phosphatase inhibitor that prevents streptomycin from getting access to the target site. Hence, the organism is not harmed by its own antibiotic.</u>
Fermentation occurs in anaerobic respiration, and produces less energy than in aerobic respiration due to the lack of ETC because oxygen is not present.
Answer:
it´s <u><em>B</em></u> the answer is B
Explanation:
thats just the answer i think not too sure really but feel free to correct me is you like my dude.
