Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
anwser:
A
Explanation:
calibrated to test and see if the temperature correctly
They are like a baseball because they are both... sphere-like? and made of different components?
They are like a baseball team <span>because part of both of them have different roles they have to perform. There must be communication between the these parts, to achieve certain goals. For these cells, to survive, and for a baseball team, to win.
(Hope this helps)
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Answer:
<em>ATP synhtesis in both chloropasts and mitochondria involves the process called CHEMIOSMOSIS.</em>
<em>Explanation:</em>
<em>Chemiosmosis is when ions move by diffusion across a semi permeable membrane , such as the one inside mitochondria. The function of this process is the production of adenosine triphosphate (ATP), that is the main molecule utilized for energy by the cell. Eukaryotics cell produces ATP during cellular respiration in the mitochondria .</em>
