The hiv protein that is involved in attachment of the virus to cell surface proteins on the macrophage is Gp120.
The virus's capacity to cling to cell surface proteins on macrophages contributes to its ability to survive in the body. The CD4 component of the cell surface is particularly attractive to this HIV protein, gp120. It is difficult for immune system cells (macrophages) to eradicate or remove HIV infection when gp120 attaches to CD4 strongly enough.
<h3>What is HIV infection?</h3>
HIV infection is the presence of HIV in the body. It can be contracted through contact with blood or other bodily fluids that contain the virus, such as sexual fluids. Once infected, it becomes virtually impossible to recover from and requires long-term treatment.
There are a number of ways that you may become infected with HIV, including receiving contaminated blood products, sharing needles for drugs or tattoos, being exposed to open wounds where there may have been mucous discharge from an AIDS patient, or engaging in unprotected sex with someone who is infected.
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The alternative pathway of complement useful in the early stages of an infection because <u>It's faster than the other complement pathways</u>.
The alternative pathway is one of three complement pathways that opsonize and kill pathogens. This pathway is activated by viruses, fungi, bacteria, immunoglobulin A and forms an important part of the defense mechanism independent of the immune response.
The alternative pathway (AP) is slowly activated spontaneously by hydrolysis of the internal C3 thioester bond [12–14] and further triggered by contact with various proteins, lipids and carbohydrate structures on microorganisms and other foreign surfaces [1, 15].
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