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<span>In vitro fertilization
Not much to say, the question pretty much defines the technique. The first successful birth via IVF happened with the birth of Louise Brown in 1978. There are some issues with IVF that can cause complications. Among them are multiple births (twins or triplets) due to multiple blastocysts successfully implanting in the woman's uterus.</span>
Mammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Recent gene knockout approaches in mice have revealed that many factors previously considered important for fertilization are largely dispensable, or if they are essential, they have an unexpected function. These results indicate that what has been observed in in vitro fertilization (IVF) differs significantly from what occurs during “physiological” fertilization. This Review focuses on the advantages of studying fertilization using gene-manipulated animals and highlights an emerging molecular mechanism of mammalian fertilization.
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