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Anions are solvated in protic hydrogen-bonding solvents (such as ethanol). Consequently, nucleophiles are less reactive. Since soft nucleophiles are less strongly solvated than hard nucleophiles, these solvents boost the relative reactivity of soft anions.
<h3>
Ethanol is either a nucleophile or a base.</h3>
The ethanol is a base Because carbocation is an extremely reactive species, a base or nucleophile as weak as ethanol can replace or remove it. SN1 and E1 would not be conceivable without the carbocation or a strong departing group.
<h3>How do solvents impact anionic nucleophile's reactivity?</h3>
In polar aprotic solvents, nucleophilic substitution reactions of anionic nucleophiles often proceed more quickly. The normal relative reactivity order in such solvents (like DMSO)is Anions are solvated in protic hydrogen-bonding solvents (such as ethanol). Consequently, nucleophiles are less reactive.
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