The right answer is: it affects the excretory function of the organism.
Take the example of chronic kidney disease (CKD).
Each minute, about 1 liter of blood is filtered by the kidney (1/5 of the amount pumped by the heart). Chronic kidney disease (or chronic renal failure) is a serious condition that causes a gradual and irreversible deterioration of the kidneys' ability to filter blood and excrete certain hormones. The excess of water and the waste metabolism products pass less into the urine and accumulate in the body.
Bones are living tissue which have their own blood vessels and are made of various cells, proteins, minerals and vitamins. This structure enables them to grow, transform and repair themselves throughout life.During childhood and adolescence, cartilage grows and is slowly replaced by hard bone.That is why children bones are a little harder to break but adult bone a little easier to break because there bone gets harder when they grow :)
Hope this helps :)
they use natural selection because they got separated from their kind and have to make new living also they need to adapt to the environment