Question

Refer to the Biochemistry in Focus section of your text for this chapter to answer this question Hyperglycemia in individuals with diabetic neuropathy leads to the inhibition of pyruvate dehydrogenase complex in the dorsal root ganglion Which additional process will be inhibited in the dorsal root ganglion under conditions that cause diabetic neuropathy?
a) glycolysis
b) lactic acid fermentation
c) the citric acid cycle
d) the glyoxylate cycle

Answer 1

Answer:

C

Explanation:

pyruvate dehydrogenase is the enzyme which catalysis pyruvate to acetyl Co -A. Thus,it  ensures the formation of link reaction/ bridge reaction for linking glycolysis with Citric acid cycle. Therefore, inhibition of this enzyme, prevent link reaction, and there reduction in pyruvate utilization and therefore prevent the  commencements of Citric acid cycle, with consequent  reduction in glucose oxidation. as there is no  reaction of acetyl Co A (from link reaction from pyruvate )   with 4C oxaloacatate in the kreb Cycle to form Citrate in Kreb's cycle. Thus the heart  depends on fatty acid supply for energy.