Question

Describe the typical principles used to identify topogenic sequences within proteins and how these can be used to develop computer algorithms. How does the identification of topogenic sequences lead to prediction of the membrane arrangement of a multipass protein? What is the importance of the arrangement of positive charges relative to the mem, brane orientation of a signal-anchor sequence

Answer 1

Answer: The peptide sequence that is essential for protein insertion, orientation in membrane and for travelling into particular organelle is called a topogenics.

Explanation: Integral membrane proteins are found in all cellular membranes and carry out many of the functions that are essential to life. The membrane-embedded domains of integral membrane proteins are structurally quite simple, allowing the use of various prediction methods and biochemical methods to obtain structural information about membrane proteins.