Bone homeostasis is a complex process by which osteoclasts resorb bone and osteoblasts engage in new bone tissue formation. This sequence has to be controlled and and planned in order to maintain skeletal integrity of bones.
Calcium homeostasis is related to bones physical properties because play a crucial role in skeletal muscle maintenance by acting as mitogen-activated protein kinase (MAPK) signaling effector and other different pathways that is responsible for regulating cell proliferation, differentiation, and cytoskeletal restructuring .
