Answer:
The perception of pain throughout the body arises when neural signals originating from the terminals of nociceptors are propagated to second-order neurons in the spinal cord or brainstem, whereupon they are transmitted to specific higher-order brain areas (Price, 2000). Recent studies have begun to elucidate some of the molecular mechanisms underlying the transduction of noxious stimuli. Many stimuli have been found to activate ion channels present on nociceptor terminals that act as molecular transducers to depolarize these neurons, thereby setting off nociceptive impulses along the pain pathways (Price, 2000; Costigan and Woolf, 2000). Among these ion channels are the members of the transient receptor potential (TRP) family. To date, the most studied member of the TRP family is the TRPV1 receptor. This is because it is the only one activated by capsaicin, the compound in chili pepper responsible for its “hot” taste; also, inhibiting TRPV1 has been shown to have therapeutic value (DiMarzo et al., 2002; Cortright and Szallasi, 2004). Although we will focus on the presence of these channels in nociceptors, we note that they have been identified in many other cell types and in various cortical and subcortical areas (Toth et al., 2005). The transient receptor potential vanilloid 1 (TRPV1) channel is predicted to have six transmembrane domains and a short, pore-forming hydrophobic stretch between the fifth and sixth transmembrane domains (see Figure 5.1A). It is activated not only by the vanilloid capsaicin (Caterina et al., 1997), but also by noxious heat (>43°C) and low pH (Caterina et al., 1997; Tominaga et al., 1998), voltage (Gunthorpe et al., 2000; Piper et al., 1999), and various lipids (Julius and Basbaum, 2001; Caterina and Julius, 2001; Clapham, 2003; Cortright and Szallasi, 2004, Szallasi and Blumberg, 1999; Prescott and Julius, 2003; Jung et al., 2004; Bhave et al., 2003). In cells, TRPV1 is inactivated by its binding to PIP2 and is released from this block by PLC-mediated PIP2 hydrolysis (Prescott and Julius, 2003). TRPV1 is widely expressed in central nervous system (CNS) tissue and highly expressed in sensory neurons of the dorsal root ganglion [19]. This receptor also localizes to neurons that line the oral and nasal cavities [10], where it is found in a subpopulation of sensory afferent nociceptive nerve fibers [20].
(this is for question 1.)
Explanation:
2) One value might be distorted; for example it is usual that a heard rate right after sitting down can be higher than the rest rate. Other factors that might affect this is the rate of breathing, exercise. We also have that some bleeding can affect this. Finally, the point that you use to measure the heart rate can also be important in making correct measurements.
1)Taking multiple heart rates leads to more reliable results because you can use the mean and not a single value that might be far off it. You avoid thus the effects of the factors above that happen often enough so that we would appear to be ill many times when we are perfectly healthy; In scientific terms, there is some variance in measurements and that is fine.
3) Even if their resting heart rates are the same, they can react differently to stress. One reason is having low iron in your blood; it is essential for transferring oxygen in your blood and thus it is esssential when one does gymnastics. A person with low iron will have a higher pulse to accomodate his cells' needs for oxygen. The same applies to persons with breathing problems or different fitness (even if the resting heart rate is the same). Also, there could be the case that genetically one has less mitochondria and this also affects oxygen and blood needs in exercise.
4) The average rate for adults is 60-100 beats per minute. While this is not abnormal, it is rather high. An examination might be advised to see what leads to such a high bpm rate. If this yields nothing, it could be that due to age and physics reasons this is normal.
Answer: The answer is 4
Explanation:
Vitamin D controls your skin pigment. It's kind of like when someone has an iron deficiency they get bruises and they turn a whiter shade.
Hope I helped :)
The answer for this question is pairs of nitrogen bases
