Answer:
Umm... What's the question?
Explanation:
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer:
Nonsense mutations
Explanation:
Premature termination of translation is caused by Nonsense mutations.
It's at mutation that occurs in the mRNA when a stop codon is produced through substitution, insertion or deletion within the region that encodes the polypeptide in the wild‑type mRNA.
Answer:
How do I offspring inherit genetic information from their parents?
Offspring inherits genetic information during mating of parents which leads to fertilization and formation of a zygote (offspring) and such genetic information are expressed phenotypically and are shown physically which could be in height, length of tail, skin color, among others
Explanation:
Answer:
A. Vaccines
Explanation:
These are meant to prepare the body for the possibility of infection by building up immunity.
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