Answer:Evaluation of blood–material interaction suitability is based on the correlation of biologic responses to physicochemical property measurements of the material for blood-contacting application
Explanation:
Empirical statistical approach is the foremost evaluation means for understanding blood–material interactions, and the clinical application of many blood-contacting devices. Here, results or available experimental data in humans, may likely be extrapolated to humans from relevant animal studies, these is likely to guide in the development of new designs for blood-contacting devices.
A theoretical approach also applies in evaluation as this helps us understand how membrane structure relates in its transport properties infering to probable deciding factors such as pore radius, pore shape, porosity, tortuosity, diffusion coefficients and protein adsorption potential.
As one interprets the experimental data one should pay attention to coefficients related to the following ;
Static, agitated, or shear flow models that comes in handy when performing hemocompatibility studies
evaluations concerning the attachment of blood cells, adsorption of proteins, and generation of thrombus and fibrin networks.
incubation of the test material with fresh human blood, cell counts, hemolysis, and the activation of platelets, leukocytes, coagulation and complement system before and after.
