<span>The notion of hybrid orbitals was "invented" by Linus Pauling in 1931 to explain the observed geometry of mostly organic molecules. Today, we find that hybrid orbitals are pretty much confined to the central atoms found in the second period of the periodic table. Periods 3 and up .... not so much.
(a) H2O ..... O is the central atom, tetrahedral, sp3 hybridization (b) PBr5 .... P is the central atom, maybe sp2 for the three equatorial bonds * (c) COCl2.. C is the central atom, trigonal planar, sp2 hybridization </span>
The fate of a protein with an N-terminal hydrophobic sorting signal and an additional internal hydrophobic domain of 22 amino acids.When it is in the translocation channel and emitted laterally into the membrane, the hydrophobic region is known as a trans-membrane domain.
