Answer:
<u>A: Hernando de Soto and almost half his men died from such things as disease, exposure, and Indian attacks.</u>
<u>D: Smallpox spread throughout the region killing about one-third of the Native American population</u>
<u>Explanation:</u>
Indeed, the arrival of the Spanish explorer, Hernando de Soto (c. 1500 – May 21, 1542) was met with much resistance by the Native Americans (Indians). Secondly, Hernando's men had transmittable diseases like measles, smallpox, and chickenpox which caused the death of almost half of his men, and they also infected the natives who came in contact with them.
Sadly, <u> Smallpox spread throughout the region killing about one-third of the Native American population</u> because they lacked the immunity which the Spaniards had acquired.