Answer:
Mental Health Effects. Chronic use of some drugs can lead to both short- and long-term changes in the brain, which can lead to mental health issues including paranoia, depression, anxiety, aggression, hallucinations, and other problems. hope that helps!
I'm not sure if you have choices or not but many abusers use substances to numb feelings in order to avoid negative feelings.
Numb
Answer: digestive and excretory completes the sentence.