Question

Exposure of zebrafish nuclei to meiotic cytosol resulted in phosphorylation of NEP55 and L68 proteins by cyclin-dependent kinase 2. NEP55 is a protein of the inner nuclear membrane, and L68 is a protein of the nuclear lamina. What is the most likely role of phosphorylation of these proteins in the process of mitosis?

Answer 1

Answer: THEY ARE INVOLVED IN THE DISASSEMBLY OF THE NUCLEAR ENVELOPE

Explanation: The disassembly of the nuclear envelope is triggered by the cyclin‐dependent kinase at the onset of mitosis. At this point, Integral nuclear membrane proteins diffuse/move into the endoplasmic reticulum (ER) after nuclear envelope breakdown. The nuclear envelope reassembles around compact chromosome mass at late anaphase/telophase and the chromosomes condenses and become visible.