Answer:
DNA vaccines consist of DNA vectors or plasmids (small double-stranded DNA rings originally derived from bacteria, but unable to cause infection) into which the genes encoding one or more immunizing proteins of the infectious agent have been inserted causing the disease to be prevented.
Explanation:
Vectors are the functional unit of naked DNA vaccines. Genes that encode the proteins of interest and are of bacterial origin are inserted into these vectors. Bacterial plasmids are circular DNA molecules that self-replicate extrachromosomally in bacteria. The genes encoded in these plasmids are under the control of promoters, almost always of viral origin. When a plasmid is introduced into the cell it translocates to the nucleus, where transcription of the transgene begins; the transcripts are then taken to the cytoplasm and translated there. The newly synthesized proteins are degraded in the proteasome to 8-10 amino acid peptides, which are transported to the endoplasmic reticulum. Peptides of high affinity with their respective MHC I molecule stabilize and enter the secretory pathway, thus reaching the cell surface, where they are coupled with the T-lymphocyte receptor (TcR) present on the surface of T lymphocytes cytotoxic drugs (CD8 +) to induce their activation.
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The four important characteristics of respiratory surface are:
1. Thin walls
2. Moisture
3. Large surface area
4. Blood supply
Respiratory system or respiratory tract is divided into upper and lower tract. Upper respiratory tract includes nose and its cavities, sinuses, pharynx and the part of the larynx. Lower respiratory tract consists of the trachea, bronchi, bronchioles and the alveoli.
Alveoli are the ends of the respiratory tract the smallest units in it. Alveoli are small folded air sacs that are branching off from alveolar ducts and providing an extremely large surface area for the gas exchange. Gas exchange occurs thanks to small blood vessels – capillaries that surround alveoli and it occurs via the process of diffusion.
So, respiratory surface is thin membrane also known as the blood–air barrier that consists of the alveolar epithelial cells, their basement membranes and the endothelial cells of the alveolar capillaries.
Circulatory system pumps blood from the heart to the lungs to get oxygen. The heart then sends oxygenated blood through arteries to the rest of the body. The veins carry oxygen-poor blood back to the heart to start the circulation process over. Your circulatory system is critical to healthy organs, muscles and tissues.
The ATP molecule is a high energy molecule. When a molecule of ATP breakdown, it produces chemical as well as thermal energy. The type of energy produced is mainly depends on the application for example, if the ATP breaks down to ADP, it produces thermal energy and if couples with a cellular process it produces chemical potential.
Our body needs energy to carry out cellular functions and the energy produced in a form of ATP is taken by cells to perform functions.
