Answer: That would depend on a person's beliefs
Explanation:
To be point of fact the black plague was mostly the reason the European population died. how it was spread no one knows for sure some believe it was the air (doctors used to wear masks that looked like the face of a bird, they believed it protected them), some believe it was the fleas on the black rats.
the Black plague actually inspired the image of death, whenever you see the scathe Death is holding, that symbolized the black plague. was placed there by the church if I remember correctly and it was inspired by how the farmers cut the grains during that time. the lives of people during that plague were "cut" very easily (it might have been due to the fact they only took a shower once a year and were not exactly very knowledgeable about how bacteria spreads).
Not only were the people knowledgably in the dark during that time but also literally. there is actual scientifically proven of the people during the dark ages not being able to see the sun, the reason for that was because a volcano somewhere in the ocean (can't remember where) erupted. the explosion was so big that it sent ash into the atmosphere causing the sun to be covered.
So literally they were in the dark not from just knowledge but also from the lack of sun.
I think that the lack of knowledge of bacteria, the lack of sun light and the lack of bathing caused the Black plague to affect so many people because already their immune systems were affected.