1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Ganezh [65]
3 years ago
9

Indicate whether each of the following mutations would likely promote or inhibit apoptosis in cells harboring the mutation(s). E

xplain each answer. a) Mutations in the pro-apoptotic effector Bcl2 family proteins Bax and Bak that prevent their association with the outer mitochondrial membrane. b) A mutation in the BIR domain of the IAP protein DIAP1 that prevents binding to either caspases or anti-IAP proteins. c) A mutation in the anti-IAP protein Reaper that prevents its binding to the IAP proteins. d) A mutation in the CARD domain of caspase-9 that prevents its binding to Apaf1.
Biology
1 answer:
Naya [18.7K]3 years ago
7 0

Answer:

<h2>Inhibiting Apoptosis:</h2>

Mutations in the pro-apoptotic effector Bcl2 family proteins Bax and Bak that prevent their association with the outer mitochondrial membrane

(Bax and Bak induce the release of cytochrome C which induces apoptosis)

A mutation in the anti-IAP protein Reaper that prevents its binding to the IAP proteins

(IAP proteins are inhibitors of the Apoptosis)

A mutation in the CARD domain of caspase-9 that prevents its binding to Apaf1.

(Apoptotic signals cause the release of cytochrome c from mitochondria and activation of apaf-1, which then cleaves the pro-enzyme of caspase-9 into the active dimer form. The CARD domain is needed to induce this cleavage)

<h2>Promoting Apoptosis:</h2>

A mutation in the BIR domain of the IAP protein DIAP1 that prevents binding to either caspases or anti-IAP proteins

(There is the loss of inhibition of apoptosis and therefore the caspases are free to function)

You might be interested in
Which of the following is the most important reason to maintain a high level of cardiovascular health?
alexandr402 [8]

Answer:

C

Explanation:

I think because the more healthier you are, the longer you'll live

5 0
3 years ago
What happens when both numerator and denominator are negative?
jok3333 [9.3K]
The fraction will be positive . because negative and negative cancels
3 0
3 years ago
Which of these organisms lacks nervous tissue? A. sponge B. jellyfish C. nematode D. earthworm
chubhunter [2.5K]
The answer is A. Sponge.
7 0
3 years ago
Read 2 more answers
Do all animals share a common ancestor?
Nastasia [14]

Answer:

The most recent common ancestor of all currently living organisms is the last universal ancestor, which lived about 3.9 billion years ago. ... 6,331 groups of genes common to all living animals have been identified; these may have arisen from a single common ancestor that lived 650 million years ago in the Precambrian.

6 0
3 years ago
Which statement best describes heating by radiation
olasank [31]

Answer:

did you get the answer yet

7 0
2 years ago
Read 2 more answers
Other questions:
  • A person's mental and emotional condition can have no effects on their overall health.
    11·1 answer
  • If uric acid accumulates in joints of humans the condition is referred to as
    10·1 answer
  • A full moon appears white to us on earth because it A) emits white light B) reflects the light from earth C) reflects the light
    8·2 answers
  • Why dose a necturus look the way it dose​
    14·1 answer
  • Match the eukaryotic kingdom with the appropriate description
    13·2 answers
  • Nyatakan emapat faktor yang mempengaruhi kadar transpirasi tumbuhan? ​
    10·1 answer
  • how does selective breeding and natural selection is simallar to apples ??? PLS HELP NOW I GIVE POINT AND BRAINLIST
    13·2 answers
  • Where does pollination takes place in the flower
    9·1 answer
  • Why do scientists use Punnett squares?
    7·2 answers
  • to test the smell of a substance, partially fill your lungs with air and, while standing slightly back from the fumes, use your
    8·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!