Such as A - coma.
A very extreme side effect or rather end effect of depressants can be, besides the mentioned loss of coordination, slurred speech, etc. also coma.
This can happen in very extreme cases and also only in a small percentage. Coma as a side effect is usually (And of course) not desired.
The answer is; Porosity which affects soil texture
The largest particle size is referred to as sand, medium is silt, while the small particles are clay. Soil texture is determined by the ratio of these three in its mixture. Soil with a higher proportion of clay becomes waterlogged easily when it rains. The right kind of soil for farming is loam because it is well drained.
Annual plants germinate, bloom, set seed and die all in one year. Biennial plants have a life cycle of two years so they germinate and grow one year, bloom and die the following. Everything which lasts longer than two years is Perennial, which in practical terms usually means it grows and flowers for many years.