The symptoms do not appear immediately after the entry of sporozoites because hemozoin is not released. Only after the release of hemozoin the malarial symptoms are released. For most people, symptoms begin 10 days to 4 weeks after infection, although a person may feel ill as early as 7 days or as late as 1 year later.
Answer:
The correct order is
Prophase l , Metaphase l, Anaphase I, Telophase l, Prophase ll, Metaphase II, Telophase ll / Cytokinesis ll
Explanation:
In Meiosis there are total two phases - Meiosis I and Meiosis II and each phase consists of total six sub phases which are as follows -
Meiosis I
1. Prophase I
2. Prometaphase I
3. Metaphase I
4. Anaphase I
5. Telophase I
6. Cytokinesis I
Meiosis II
1. Prophase II
2. Prometaphase II
3. Metaphase II
4. Anaphase II
5. Telophase II
6. Cytokinesis II
Hence the correct order is
Prophase l , Metaphase l, Anaphase I, Telophase l, Prophase ll, Metaphase II, Telophase ll / Cytokinesis ll
Answer:
c. Pyridostigmine binds to the acetylcholinesterase active site and prevents sarin from binding to and modifying the enzyme active site.
Explanation:
Sarin is a toxic compound which inhibits acetylcholinesterase enzyme. This enzyme degrades the neurotransmitter acetylcholine after the required muscle cell stimulation. In absence of its activity, acetylcholine is not degraded and the muscle cells are stimulated uncontrollably. The muscles are not able to relax which ultimately proves fatal for the victim.
Pyridostigmine is also an acetylcholinesterase inhibitor like Sarin. However its period of inhibition is short compared to organophosphorus inhibitors like sarin. It competes with sarin and replaces it in the active site of acetylcholinesterase. The enzyme is still inhibited but for a shorter time as compared to inhibition by Sarin. Hence after sometime, it becomes functional again and resumes its normal activity. Acetycholine starts getting degraded relaxing the muscles.
