My best guess would be the first answer
Negative symptoms take place when there is a lack of a particular response in the system. With regards to our immune system, it is very essential that our body needs to respond against the pathogens attacking our cell. The response would result to the production of antibodies that would help eliminate these threats.
I think it has had a positive effect.
Hope this helps.
The most important nutrients for people with osteoporosis are calcium and vitamin D. Vitamin D helps your body to absorb calcium.