The cAMP <span>activates an activator protein in the lac operon</span>
Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
<u>Answer:</u>
The “wheelchair belt” mechanism is the most important mechanism to have on the wheel chair.
<u>Explanation:</u>
- As the patient have very poor control over his trunk so a belt will be perfect to prevent him from falling out of the wheelchair anytime.
- The other options doesn’t make much of important sense than a belt for the patient with muscular dystrophy needs, especially when lost control over the extremities.
- The wheelchair belt will help him in staying in the wheelchair freely without risk of falling off.
Answer:
I don't know if this is what you mean, but here is what I read it as:
1. can be simplified to "1"
2. can be simplified to "3/4"
3. cannot be simplified so it remains "3/4"
4 can be simplified to "1/2"