Answer:
Both contain genetic material, in the form of DNA and/or RNA. Both of them can replicate, that is, produce more organisms similar to themselves. ... They require a host cell to carry out life processes, such as replication and carrying out genetic instructions, etc. Bacteria are relatively bigger in size than viruses.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The hypohidrosis is a condition, in which the sweating ability is diminished in a person. This condition may cause severe threats, if complete absence of the sweating occurs. The complete absence of sweating is known as anhidrosis.
The hypohydrosis can lead to long lasting hyperthermia, as the body is not able to lose heat through sweating. It can also cause heat stroke, heat exhaustion, and in severe cases, it may result to death.
hence, the correct answer is hypohidrosis.
Answer:
To make sure that the experiment is accurate, the scientist must make carry out an appropriate observation, which would lead to the formation of good hypothesis. Good experimental method is an other criteria to look forward for the accurate experimental results. Methods are applied in collection of data and other things and in compiling results using statistical methods to carry out an accurate experiment.
