Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Well he looked at the contents and saw they some of them had similar shapes so
The ribosomes that is synthesizing the protein is directly attached to the ER membrane
Tropical Rainforest- >250 cm precipitation; 25c
Taiga- 101 cm precipitation - rain and snow; 15c
Tundra- no more than 25 cm precipitation in wettest month; <10c
Desert- <25 cm precipitation; 25c
These are the answers that were correct when i took this test. Hope this helps
Answer:
By researching, I would think that the answer is D. Ice crystals melt as they fall through a warm layer of air and then refreeze into small ice pellets as they pass through a colder layer of air.
Explanation:
<em>During precipitation formation, if temperatures are at or below freezing, 0°C (32°F), at cloud level, water in the air freezes into ice crystals, and the crystals stick together to make snow. The snow starts to fall, and if the air column is freezing cold all the way down from the clouds to the ground, the precipitation stays frozen. It simply falls as snow.</em>
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<em>Sometimes, however, a temperature inversion occurs. Normally, the temperature decreases with increasing altitude. A temperature inversion is when a layer of warm air intrudes between the ground and the clouds.</em>
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<em>Under these conditions, when the falling snow reaches the layer of warm air, it melts. Then it hits the layer of cold air just above Earth’s surface and refreezes. This all happens very fast, and the result is tiny ice pellets called sleet.</em>
