<span>the nonlexical component of communication by speech,for example intonation, pitch and speed of speaking, hesitation noises, gesture, and facial expression. hope it helps</span>
i think its B dont come for me if not tho
Answer:
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ T regulatory cells) and B cells are involved in this disorder, thus new MS therapies seek damage prevention by resetting multiple components of the immune system. The currently approved therapies are immunoregulatory and reduce the number and rate of lesion formation but are only partially effective. This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation. The translational options target oligodendrocyte protection and myelin repair in animal models and assess their relevance in human. Remyelination may be enhanced by signals that promote myelin formation and repair. The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.Keywords: calpain, central nervous system, demyelination, fingolimod, glycolipids, lipids, multiple sclerosis, myelin, myelination, NKT cells, oligodendrocytes, remyelination, T cells
Explanation:
<span>Genes are the main cause of a Carabelli Cusp.
This is a condition where there is an additional cusp on the first molar of the
tooth and become less pronounce when progressing to the second and third
molars. In some cases, the cusps' forms included pits, ridges, and furrows. <span>
<span>The Carabelli
Cusp is a condition most common in Europeans and rarest in the Pacific Islands.
It is an inherited feature from a homozygote or a heterozygote gene that can be
present or absent in some
individuals. It was
discovered in the year 1842 by Georg Carabelli, a court dentist of the Austrian
Emperor Franz. </span></span></span>
