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Answer: The virus weakens as time passes.
Explanation: The virus will weaken continuously during transmission, and will reduce its toxicity after several generations of transmission, without causing much harm to the human body.
Mitochondrial DNA can be traced for generations. It is because of the fact that unlike nuclear DNA, mitochondrial DNA rarely gets mutated. The frequency of mutations in the mitochondrial DNA is approximately one every 3,500 years per nucleotide. That is why mitochondrial DNA of a person is almost similar to his/her direct maternal ancestor. So, it can be used to match lineages amongst people.
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Answer:
c. in renal dysfunction, dosage reduction is necessary to avoid seizures
Explanation:
Imipenem is an antibiotic which is given in combination with cilastatin. It is used to treat pneumonia, joint infections, urinary tract infections, sepsis etc. It kills bacteria by interfering with its cell wall formation process. It is metabolized in kidney reducing its half life so cilastatin is given with it to halt its renal metabolism.
Imipenem belongs to carbapenem family of antibiotics. Carbapenem antibiotics can cause seizures specially in people with nervous system disorders or renal failure. Dose must be reduced in patients with renal (kidney) dysfunction otherwise patient's kidneys will be damaged more and since they are already in weak state, it can prove dangerous to the patient.
