The correct answer is C.) - the Isthmus of Panama. Isthmus is a narrow strip of land and the Isthmus of Panama was the optimal place for a channel between the two oceans.
To keep the blood flowing, use chest compressions
Mesopotamia has two regions; the Sumer (south) and the Akkad (north). Sumer, the south region is the first known complex civilization, developing the first city-states in the 4th millennium BCE. It was in these cities that the cuneiform script appeared as the earliest known form of writing, in which invented by Sumerians.
The correct answer to this open question is the following.
The meaning of the religious destruction in Constantinople for Christians elsewhere in Europe must have been a devastating moment for the destruction of saints relics, churches.
The fall of Constantinople was the consequence of the victory of the Ottomans. Muslim Sultan Mehmed II conquered the capital of the Byzantine Empire in May 1453. Ottoman troops attacked Constantinople by sea and land, and after 55 days, Constantinople had fallen.
The implication of this defeat was that the Ottomans Muslims gain control over this important city and trade center than represented the heart of the Byzantine Empire and Christianity in Europe.